We are at Courant Institute, 251 Mercer St, New York, Phone: 212-992-7546

Computational modeling of cytoskeletal dynamics, cell motility, mitosis, organelle positioning and scaling

Ours is a 'dry' lab. We use mathematical and computer modeling, theoretical biophysics and systems biology tools to develop and simulate models of cytoskeletal processes. We collaborate extensively with experimentalists. Current collaborators are:
Keren lab (Technion), Khodjakov lab (Wadsworth Center), Blanchoin/Thery labs in Grenoble and Paris, Baylies lab (Sloan Kettering), Christiaen lab (NYU), Danuser lab (UT Southwestern).

Largely speaking, we are interested in understanding molecular mechanisms of regulation and mechanics of cell migration, mitosis and cell division and self-organization and assembly principles of actin-microtubule-motor machines. We also work on how nuclei are positioned and how their size is regulated.
Our major current projects are:
1. Detailed quantitative understanding of actin dynamics using in vitro systems (with Keren and Blanchoin/Thery labs).
2. Self-assembly, error correction and mechanics of mitotic spindle (with Khodjakov lab).
3. Mechanisms of galvanotaxis (with Zhao lab).
4. Mechanisms of contraction in actin-myosin networks in vitro and in yeast cells (with Blanchoin/Thery and Keren labs).
5. Positioning and size scaling of nuclei in multinucleated cells (with Baylies lab).
6. Collective cell migration (with Christiaen lab).

Our publications can be downloaded from here

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