We are at Courant Institute, 251 Mercer St, New York, Phone: 212-992-7546

Computational modeling of cytoskeletal dynamics, cell motility, mitosis, nuclear positioning and scaling

Ours is a 'dry' lab. We use mathematical and computer modeling, theoretical biophysics and systems biology tools to develop and simulate models of cytoskeletal processes. We collaborate extensively with experimentalists. Current collaborators are:
Keren lab (Technion), Khodjakov lab (Wadsworth Institute), Min Zhao lab (UC Davis), Blanchoin/Thery labs in Grenoble and Paris, Vladimir Gelfand lab (Northwestern), Wadsworth and Maresca labs (U Mass), Mary Baylies lab (Sloan Kettering), Burgess lab (Boston College), Christiaen lab (NYU), Laplante lab (NCSU).

Largely speaking, we are interested in understanding molecular mechanisms of regulation and mechanics of cell migration, mitosis and cell division and self-organization and assembly principles of actin-microtubule-motor machines. We also work on how nuclei are positioned and how their size is regulated.
Our major current projects are:
1. Detailed quantitative understanding of actin dynamics using in vitro systems (with Keren and Blanchoin/Thery labs).
2. Self-assembly, error correction and mechanics of mitotic spindle and cytokinesis (with Khodjakov and Wadsworth and Maresca labs).
3. Mechanisms of galvanotaxis (with Zhao lab).
4. Mechanisms of contraction in actin-myosin networks in vitro and in yeast cells (with Blanchoin/Thery, Keren and Laplante labs).
5. Positioning and size scaling of nuclei in multinucleated cells (with Baylies lab).
6. Mechanics and dynamics in microtubule-motor systems in Drosophila and Xenopus cells (with Gelfand and Burgess labs).
7. Collective cell migration (with Christiaen lab).

Our publications can be downloaded from here

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