Active Mechanics in the Cell
Michael Shelley, CIMS

Many fundamental phenomena in eukaryotic cells -- nuclear migration, spindle positioning, chromosome segregation -- involve the interaction of often transitory structures with boundaries and fluids. I will discuss the interaction of theory and simulation with experimental measurements of active processes within the cell. This includes understanding the force transduction mechanisms underlying nuclear migration, spindle positioning and oscillations, as well as how active displacement domains of chromatin might be forming in the interphase nucleus.