We are at Courant Institute, 251 Mercer St, New York, Phone: 212-992-7546

Who We Are

What We Do

Computational modeling of cytoskeletal dynamics, cell motility, mitosis, nuclear positioning and scaling

Ours is a 'dry' lab. We use mathematical and computer modeling, theoretical biophysics and systems biology tools to develop and simulate models of cytoskeletal processes. We also do experimental work on galvanotaxis (how cell sense electric fields). We collaborate extensively with experimentalists. Current collaborators are:
Julie Theriot lab (Stanford), Kinneret Keren lab (Technion), Alexei Khodjakov lab (Wadsworth Institute), Min Zhao lab (UC Davis), Blanchoin/Thery labs in Grenoble and Paris, Vladimir Gelfand lab (Northwestern), Anna Kashina lab (U Penn), Rong Li lab (Johns Hopkins), Pat Wadsworth lab (U Mass), Mary Baylies lab (Sloan Kettering).

Largely speaking, we are interested in understanding molecular mechanisms of regulation and mechanics of cell migration, mitosis and cell division and self-organization and assembly principles of actin-microtubule-motor machines. We also work on how nuclei are positioned and how their size is regulated.
Our major current projects are:
1. Motility of fish keratocyte cells (with Theriot and Keren labs).
2. Self-assembly, error correction and mechanics of mitotic spindle (with Khodjakov and Wadsworth labs).
3. Mechanisms of galvanotaxis (with Zhao lab).
4. Dynamics of protrusive and contractile actin networks in vitro (with Blanchoin/Thery/Paterski lab).
5. Positioning and size scaling of nuclei in multinucleated cells (with Baylies lab).
6. Mechanics and dynamics in microtubule-motor systems (with Gelfand lab).
7. Actin transport in motile cells (with Keren and Kashina labs).
8. Collective cell migration (with Rong Li lab).

Our publications can be downloaded

from here